A Clinical trial on oral H. pylori infection of preschool children

In the present study, we aimed to explore the existence of oral Helicobacter pylori (H. pylori) infection and treatment of preschool children. A total 178 children were recruited and evaluated using the saliva H. pylori antigen test (HPS), the urea breath test (UBT C13). The treatments included toothpaste and mouth washing solution for two months. Participants were sorted into three subgroups; A. toothpaste group, B. combinative toothpaste and mouth rinse group. C group control. The positive rate of HPS and C13 were 76% and 15% respectively. After two months treatments, toothpaste provided a 26.87% effectiveness rate in the 95% of the confidence interval (CI) ranges on the oral H. pylori infection. Toothpaste and mouth rinse provided a 26.445% effectiveness rate in the 95% of the confidence interval (Cl) ranges on the oral H. pylori infection. C group was 7.25% effectiveness rate. The difference between A or B and C were significant (p<0.001). The positive rate of HPS is significantly higher with parents suffered with stomach syptoms (p<0.001). We concluded oral H. pylori infection of preschool children exits and treatment were effectively reducing the infection. Correspondence to: Yuan Song, SuZhou Municipal Hospital of Nan Jing Medical University, Su Zhou, China, Tel: +86 25 663 7551; Fax: +86 25 33